prof. MUDr. Jiří Mayer, CSc.

 

 

 

Funkce:

 

 

 

 

 

 

  • děkan Lékařské fakulty Masarykovy univerzity
  • přednosta kliniky
  • vedoucí transplantačního programu
  • náměstek ředitele pro onkologii

 

Profesor Mayer
Telefon: +420 5 3223 3642  

E-mail:

 

 
Tituly: prof., MUDr., CSc.  

 

Masarykova univerzita, Brno

 

 

Atestace:

 

 

 

  • vnitřní lékařství I. a II. stupně
  • hematologie a transfuzní lékařství
  • klinická onkologie
 

Klinická orientace:

 

 

diagnostika a léčba hematologických malignit, zvláště leukemií a lymfomů, molekulární biologie v hematologii a onkologii, transplantace kostní dřeně a krvetvorných buněk, problematika kmenových buněk, vnitřní lékařství, intenzivní péče, hemorheologie, diagnostika a léčba infekcí u imunokompromitovaných nemocných.  

 

 

 

 

Členství v odborných organizacích:

  • ASH, American Society of Hematology
  • EHA, European Haematology Associacion
  • ASBMT, American Society for Blood and Marrow Transplantation
  • EBMT, European Group for Blood and Marrow Transplantation
  • ISEH, International Society for Experimental Hematology

 

 

 

Nejvýznamnější publikace:

Více než 300 publikací a přednášek, řada monografií.

 

  1. Mayer J., Pospíšil Z., Litzman J.: The mechanism of erythrocyte sedimentation in Westergren´s examination. Biorheology 29, 1992, 261-271.
  2. Mayer J., Hájek R., Tomíška M., Vorlíček J.: Sepsis and septic shock. Definitions, pathophysiology and treatment. Part I: Definition and pathophysiology. Support. Care Cancer 3, 1995, 106-110.
  3. Mayer J., Hájek R., Tomíška M., Vorlíček J.: Sepsis and septic shock. Definitions, pathophysiology and treatment. Part II: Treatment. Support. Care Cancer 3, 1995, 111-119.
  4. Hájek R., Vášová I., Adam Z., Mayer J.: New approaches to management of multiple myeloma. Acta Med. Austr. 23, 1996, 91-98.
  5. Skřičková J., Mayer J., Vorlíček J.: Pulmonary infiltrate etiology in leukemic patients with fever. In: Klastersky J (ed.): Febrile neutropenia. Springer Verlag, Berlin Heidelberg, 1997, 103-106.
  6. Mayer J., Kovařík A., Kubálek V. et al.: Efficacy of polymerase chain reaction for detection of deep mycotic infections: confirmation by autopsy. Mycoses 41, 1998, 471-475.
  7. Mayer J., Doubek M., Vorlíček J.: Must we really fear toxicity of conventional amphotericin B in oncological patients? Support. Care Cancer 7, 1999, 51-56.
  8. Kořístek, Z., Mayer, J.: Bone marrow processing for transplantation using the COBE Spectra Cell Separator. J. Hematother. Stem Cell Res. 8, 1999 , s. 443-448.
  9. Mayer J., Kořístek J., Vorlíček J. et al.: Ifosfamide and etoposide based chemotherapy as salvage and peripheral blood progenitor cells mobilizing regimens for poor prognosis lymphoma. Bone Marrow Transplant. 23, 1999, 413-419.
  10. Skřičková, J., Mayer, J., Merta, Z., Vorlíček, J., Špelda, S., Burgetová, D., Drašar, V., Kunderová, H., Kubálek, V., Mezenský, L., Ševčíková, A., Štroblová, M., Votava, M.: The use of bronchoalveolar lavage in diagnosis of infectious pulmonary complications in immunocompromised patients. J. Health Manag. Public Health, 5, 2000, 73-80.
  11. Mayer J., Vášová I., Kořístek Z. et al.: Ifosfamide and etoposide based chemotherapy as salvage and mobilizing regimens for poor prognosis lymphoma. Eur. J. Hematol., 66, 2001, Suppl. 64, 21-27.
  12. Krejčí, P., Dvořáková, D., Krahulcová, E., Pacherník, J., Mayer, J., Hampl, A., Dvořák, P.: FGF-2 abnormalities in B cell chronic lymphotic and chronic myeloid leukemias. Leukemia 15, 2001, 228-237.
  13. Dvořáková D., Krejčí P., Mayer J., Fajkus J., Hampl A., Dvořák P.: Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells. Brit. J. Haematol. 113, 2001, 1-5.
  14. Kořístek Z., Štěrba J., Havranová D., Mayer J.: Technique for PBSC harvesting in children of weight under 10 kg. Bone Marrow Transpl. 29, 2002, 57-61.
  15. Mayer J., Doubek M., Doubek J. et al.: Reduced nephrotoxicity of conventional amphotericin B therapy after minimal nephroprotective measures: animal experiments and clinical study. J. Infect. Dis. 186, 2002, 378-388.
  16. Obořilová A., Mayer J., Pospíšil Z., Kořístek Z.: Symptomatic intravenous antipyretic therapy: efficacy of metamizol, diclofenac, and proparacetamol. J. Pain. Symptom. Manage. 24, 2002, 608-615.
  17. Dvořák P., Dvořáková D., Doubek M., Faitová J., Pacholíková J., Hampl A., Mayer J.: Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR/ABL+ cells from patients with chronic myeloid leukemia. Leukemia 17, 2003, 2418-2425.
  18. Pavlová Š., Mayer J., Koukalová H., Šmardová J.: High frequency of temperature-sensitive mutations of p53 tumor suppressor in acute myeloid leukemia revealed by functional assay in yeast. Int. J. Oncol. 23, 2003, 121-131.
  19. Hájek R., Žáčková D., Buchler T., Penka M., Krahulcová E., Kořístek Z:, Vinklárková J., Adler J., Janovská E., Indrák K., Faber E., Doubek M., Klabusay M., Oltová A., Kuglík P., Bourková L., Dušek L., Mareschová I., Mayer J., Vorlíček J.: Treatment of chronic myeloid leukemia with autologous transplantation using peripheral blood stem cells or bone marrow cultured in IL-2 followed by IL-2, GM-CSF, and IFN-a administration. Med. Oncol. 20, 2003, 69-76.
  20. Mayer J., Pospíšil Z., Kořístek Z.: Mathematical model of peripheral blood stem cell harvest kinetics. Bone Marrow Transplant. 32, 2003, 749-757.
  21. Křivanová A., Hájek R., Krejčí M., Ščudla V., Indrák K., Bačovský J., Buchler T., Svobodník A., Adam Z., Mayer J., Vorlíček J.: Second autologous transplantation for multiple myeloma patients relapsing after the first autograft – a pilot study for the evaluation of experimental maintenance therapies. Onkologie 27, 2004, 275-279.
  22. Doubek M., Brychtová Y., Doubek R., Janků P., Mayer J.: Anagrelide therapy in pregnancy: report of a case of essential thrombocythemia. Ann. Hematol. 83, 2004, 726-727.
  23. Doubek M., Brychtová Y., Tomíška M., Mayer J.: Idiopathic systemic capillary leak syndrome misdiagnosed and treated as polycythemia vera. Acta Haematol. 113, 2005, 150-151.
  24. Krejčí M., Buchler T., Hájek R., Svobodník A., Křivanová A., Pour L., Adam Z., Mayer J., Vorlíček J.: Prognostic factors for survival after autologous transplantation: a single center experience in 133 multiple myeloma patients. Bone Marrow Transpl. 35, 2005, 159-164.
  25. Buchler T., Krejčí M., Svobodník A., Adam Z., Minařík J., Bačovsdký J., Ščudla V., Mayer J., Vorlíček J., Hájek R.: Outcome of patients with multiple myeloma and hypertension treated with angiotensin-I-converting enzyme inhibitors during high-dose chemotherapy. Hematol. J. 5, 2005, 559-564.
  26. Mayer J., Krejčí M., Doubek M., Pospíšil Z., Brychtová Y., Tomíška M., Ráčil Z.: Pulse cyclophosphamide for corticosteroid-refractory graft-versus-host disease. Bone Marrow Transpl. 35, 2005, 699-705.
  27. Doubek M., Mayer J., Lauschova I., Scheer P., Krejčířová L., Horký D., Doubek J.: Comparison of the effect of amphotericin B desoxycholate and amphotericin B colloidal dispersion on renal functions and renal morphology in rats. Nephrology 10, 2005, 57-62.
  28. Doubek M., Brychtová Y., Berkovcová J., Krejčí M., Palásek I., Dvořáková D., Mayer J.: Acute myeloid leukemias with recurrent genetic abnormalities: frequent assessment of minimal residual disease and treatment of molecular relapse with chemotherapy. Leukemia 19, 2005, 885-888.
  29. Krejčí M., Doubek M., Brychtová Y., Mayer J.: Mycophenolate mofetil for the treatment of acute and chronic steroid-refractory graft-versus-host disease. Ann. Hematol. 84, 2005, 681-685.
  30. Crawley C., Szydlo R., Lalancette M., Bacigalupo A., Lange A., Brune A., Juliusson G., Nagler A., Gratwohl A., Komarnicki M., Vitek A., Mayer J., Zander A., Sierra J., Rambaldi A., Ringden O., Niederwieser D., and Apperley J. for the Chronic Leukaemia Working Party of the EBMT. Outcomes of reduced intensity transplantation for chronic myeloid leukemia: an analysis of prognostic factors from the Chronic Leukemia Working Party of the EBMT. Blood 106, 2005, 2969-2976.
  31. Trbušek M., Malčíková J., Šmardová J., Kuhrová V., Mentzlová D., Francová H., Bukovská S., Svitáková M., Kuglík P., Linková V., Doubek M., Brychtová Y., Začal J. Kujíčková J., Pospíšilová Š, Dvořáková D., Vorlíček J., Mayer J.: Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation status and previous treatment. Leukemia 20, 2006, 1159-1161.
  32. Koutna I, Klabusay M, Kohutova V, Krontorad P, Svoboda Z, Kozubek M, Mayer J: Evaluation od CD34+ and Lin- selected cells from peripheral blood stem cell grafts of patients with lymphoma during differentiation in culture ex vivo using a cDNA microarray technique. Exp. Hematol. 34, 2006, 832-840.
  33. Doubek M., Kořístek Z., Havranová D, Šmardová L, Mayer J.: Megakaryocyte colony-forming unit growth is enhanced by alemtuzumab: in vitro experiments and a case report of acquired amegakaryocytic thrombocytopenic purpura. Leukemia 20, 2006, 1618-1619.
  34. Krejčí M, Mayer J, Doubek M., Brychtová Y, Pospíšil Z, Ráčil Z, Dvořáková D, Lengerová M, Horký O, Kořístek Z, Doležal T, Vorlíček J.: Clinical outcomes and direct hospital costs of reduced-intensity allogeneic transplantation in chronic myeloid leukemia. Bone Marrow Transplant 38, 2006, 483-491.
  35. Varga G, Volková Z, Leibl H, Gasztonyi Z, Hlusi A, Mayer J et al.: Efficacy and safety of the new intravenous immunoglobulin IGIV 10% in adults with chronic idiopathic thrombocytopenic purpura. Transfus Med Hemother 33, 2006, 509-514.
  36. Meluzín J, Mayer J, Groch L. Janoušek S, Horňáček I et al.: Autologous transplantation of mononuclear bone marrow cells in patients with acute myocardial infarction: the effect of the cell dose of transplanted cells on myocardial function. Am Heart J 152, 2006, 975.e9-975.e15.
  37. Lengerová M, Ráčil Z, Volfová P, Lochmanová J, Berkovcová J, Dvořáková D, Vorlíček J, Mayer J: Real-time PCR diagnostics failure caused by nucleotide variability within exon 4 of the human cytomegalovirus major immediate-early gene. J Clin Microbiol 45, 2007, 1042-1044.
  38. Östeborg A, Steegmann LJ, Hellmann A, Couban S, Mayer J, Eid JE: Phase II study of three dose levels of continuous erythropoietin receptor activator (C.E.R.A.) in anaemic patients with aggressive non-Hodgkin´s lymphoma receiving combination chemotherapy. Br J Haematol 136, 2007, 736-744.
  39. Klabusay M, Sukova V, Coupek P, Brychtova Y, Mayer J: Different levels of CD52 antigen expression evaluated by quantitative fluorescence cytometry are detected on B-lymphocytes, CD34+ cells and tumor cells of patients with chronic B-cell lymphoproliferative diseases. Cytometry (Part B Clinical Cytometry) 72B, 2007, 363-370.
  40. Racil Z, Kocmanova I, Lengerova M, Winterova J, Mayer J: Intravenous Plasma-lyte as a major cause of false-positive results of Platelia Aspergillus test for galactomannan detection in serum. J. Clin. Microbiol 45, 2007, 3141-3142.
  41. Hillmen P, Skotnicki AB, Robak T, Jaksic B, Dmoszynska A, Wu J, Sirard C, Mayer J: Alemtuzumab compared with Chlorambucil as first-line therapy for Chronic Lymphocytic Leukemia. J Clin Oncol 25, 2007, 5616-5623.
  42.  
  43. Meluzín J, Janoušek S, Mayer J, Groch L, Horňáček I, Hlinomaz O, Kala P, Panovský R, Prášek J, Kamínek M, Staníček J, Klabusay M, Kořistek Z, Navrátil M, Dušek L, Vinklárková J: Three-, 6-, and 12-month results of autologous transplantation of mononuclear bone marrow cells in patients with acute myocardial infarction. Int J Cardiol 128, 2008, 185 – 192.
  44. Malcikova J, Smardova J, Pekova S, Cejkova S, Kotaskova J, Tichy B, Francova H, Doubek M, Brychtova Y, Janek D, Pospisilova S, Mayer J, Dvorakova D, Trbusek M.: Identification of somatic hypermutations in the TP53 gene in B-CLL chronic lymphocytic leukemia. Mol Immunol 45, 2008, 1525-1529.
  45. Kamínek, M., Meluzín, J., Janoušek, S., Panovský, R., Mayer, J., Prášek, J., Staníček, J., Lukl, J. Individual differences in the effectiveness of intracoronary bone marrow cell transplantation assessed by gated sestamibi SPECT/FDG PET imaging. J Nuclear Cardiol 15, 2008, 392-399.
  46. Janíková, A., Bolcak, K., Pavlík, T., Mayer, J., Král, Z. Value of (18F) Fluorodeoxylucose positron emission tomography in the management of follicular lymphoma: The end of a dilemma?. Clin Lymphoma & Myeloma, 8, 2008, 287-293.
  47. Čejková, S., Ročňová, L., Potěšil, D., Šmardová, J., Nováková, V., Chumchalová, J., Zezulková, D., Borský , M., Doubek, M., Brychtová, Y., Pospíšilová, Š., Klabusay, M., Mayer, J., Trbušek, M. Presence of heterozygous ATM deletion may not be critical in the primary response of chronic lymphocytic leukemia cells to fludarabine. Eur J Haematol 82, 2008, 33-142.
  48. Panovský, R., Meluzín, J., Janoušek, S., Mayer, J., Kamínek, M., Groch, L., Prášek, J., Staniček, J., Dušek, L., Hlinomaz, O., Kala, P., Klabusay, M., Kořístek, Z., Navrátil, M. Cell therapy in patients with left ventricular dysfunction due to myocardial infarction. Echocardiography 25, 2008, 888-897.
  49. Tomenendalova, J., Mayer, J., Doubek, M., Horký, D., Řeháková, K., Doubek, J. Chlorambucil and fludarabine as a new pre-transplant conditioning for patients with chronic lymphocytic leukemia: results of in vivo experiments. Vet Med, 53, 2008, 564-571.
  50. Válková, V., Benešová, K., Vítek, A., Faber, E., Mayer, J., Žák, P., Trněný, M. The results of allogeneic transplants in patients with malignant lymphoma-a retrospective analysis of data from the Czech National Registry. Neoplasma 56, 2009, 76-83.
  51. Staňo-Kozubík, K., Malčíková, J., Tichý, B., Kotašková, J., Borský, M., Hrabčáková, V., Francová, H., Valášková, I., Bourková, L., Šmardová, J., Doubek, M., Brychtová, Y., Pospíšilová, Š., Mayer, J., Trbušek, M. Inactivation of p53 and amplification of MYCN gene in a terminal lymphoblastic relapse in a chronic lymphocytic leukemia patient. Cancer Genetics and Cytogenetics 189, 2009, 53-58.
  52. Dvořáková, D., Lengerová, M., Pospíšilová, J., Palásek, I., Mayer, J. A novel quantitative assessment of minimal residual disease in patients with acute myeloid leukemia carrying NPM1 (nucleophosmin) exon 12 mutations. Leukemia, 2008, prepublished online.
  53. Mráz, M., Malinová, K., Kotašková, J., Pavlová, Š., Tichý, B., Malčíková, J., Staňo-Kozubík, K., Šmardová, J., Brychtová, Y., Doubek, M., Trbušek, M., Mayer, J., Pospíšilová, Š. miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities. Leukemia, 2009, prepublished online.
  54. Mráz M, Pospíšilová Š, Malinová K, Šlapák I, Mayer J.: MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtypes. Leukemia & Lymphoma 50, 2009, 506–509.
  55. Meluzín, J., Vlašín, M., Groch, L., Mayer, J., Křen, L., Raušer, P., Tichý, B., Horňáček, I., Sitar, J., Palša, S., Klabusay, M., Kořístek, Z., Doubek, M., Pospíšilová, Š., Lexmaulová, L., Dušek, L. Intracoronary delivery of bone marrow cells of the acutely infarcted myocardium. Optimization of the delivery technique. Cardiology 112, 2009, 98-106.
  56. Adam, Z., Pour, L., Veselý, K., Krejčí, M., Fakan, F., Hofstädter, F., Büchler, T., Hájek, R., Mayer, J.: Interdigitating dendritic cell sarcoma of the leg. Onkologie 32, 2009, prepublished online.
  57. Doubek, M., Palásek, I., Pospíšil, Z., Borský , M., Klabusay, M., Brychtová, Y., Jurček, T., Ježišková, I., Krejčí, M., Dvořáková, D., Mayer, J. Detection and treatment of molecular relapse in acute myeloid leukemia with RUNX1 (AML1), CBFB, or MLL gene translocations: Frequent quantitative monitoring of molecular markers in different compartments and corelation with WT1 gene expression. Exp Hematol 37, 2009, 659-672.t
  58. Landlinger C, Preuner S, Willinger B, Haberpursch B, Racil Z, Mayer J, Lion T.: Species-specific identification of a wide range of clinically relevant fungal pathogens by use of Luminex xMAP technology. J Clin Microbiol 47, 2009, 1063-1073.
  59. Doubek, M., Folber, F., Kořístek, Z., Brychtová, Y., Krejčí, M., Tomíška, M., Navrátil, M., Mikulášová, P., Mayer, J. Autologous hematopoietic stem cell transplantation in adult acute lymphoblastic leukemia: still not out of fashion. Annals of Hematology, 2009, roč. 88, č. , s. 881-887.
  60. Rázga, F., Dvořáková, D., Jurček, T., Ježíšková, I., Křístková, Z., Mayer, J. CEBPA gene mutational status. A complete screening using high-resolution melt curve analysis . Molecular diagnosis and therapy, 2009, roč. 13, č. 3, s. 195-200.
  61. Mayer, J., Krejčí, M., Pospíšil, Z., Doubek, M., Janíková, A., Žáčková, D., Ráčil, Z., Šmardová, L., Navrátil, M., Kamelander, J. Successful treatment of steroid-refractory hepatitic variant of liver graft-vs-host disease with pulse cyclophosphamide. Experimental Hematology, 2009, roč. 37, č. 6, s. 767-773.
  62. Janíková, A., Mayer, J., Křen, L., Šmardová, J., Dvořáková, D., Neubauer, J., Vášová, I. The persistence of t(14;18)-bearing cells in lymph nodes of patients with follicular lymphoma in complete remission: the evidence for ´a lymphoma stem cell´. Leukemia and Lymphoma, 2009, roč. 50, č. 7, s. 1102-1109.
  63. Finke Jürgen, Bethge A.,W., Schmoor C., Ottinger D.H., Stelljes M., Zander R.A., Volin L., Ruutu T., Heim A., D., Schwerdtfeger R., Kolbe K., Mayer J., Maertens A.,J., Linkesch W., Holler E., Koza V., Bornhäuser M., Einsele H., Kolb J.,H., Bertz H., Egger M., Grishina O., Socié G. Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantion from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial. Lancet 2009, prepublished online.

 

 

 


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